Take into account alternant therapies that are not moderate CYP3A inducers throughout therapy with mitapivat. If unable to stay away from coadministration, keep track of Hb and titrate past fifty mg BID, if important, but will not exceed mitapivat dose of one hundred mg BID. .
pentobarbital will lower the extent or effect of disopyramide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.
Stay away from coadministration of ganaxolone with moderate or potent CYP3A4 inducers. If coadministration unavoidable, take into consideration expanding ganaxolone dose; on the other hand, tend not to exceed highest daily dose for bodyweight.
Warning when discontinuing CYP3A4 inducers which can be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may raise and may end up in potentially deadly respiratory depression.
pentobarbital will minimize the level or impact of bedaquiline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Prevent coadministration of bedaquiline with potent CYP3A4 inducers because of likely for diminished therapeutic influence
pentobarbital will lessen the level or influence of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
pentobarbital will minimize the extent or result of maraviroc by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will decrease the extent or outcome of conjugated estrogens, vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lessen the extent or influence of etoposide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the level or impact of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will minimize the extent or result of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or effect of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. get more info Contraindicated.
pentobarbital will reduce the extent or result of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.